Structural, Pro-Inflammatory and Calcium Handling Remodeling Underlies Spontaneous Onset of Paroxysmal Atrial Fibrillation in JDP2-Overexpressing Mice.
Mariana S ParahulevaJens KockskämperJacqueline HegerWolfram GrimmAnna SchererSarah BühlerJulian KreutzRainer SchulzGerhild EulerPublished in: International journal of molecular sciences (2020)
JDP2 is an important regulator of atrial calcium and immune homeostasis and is involved in the development of atrial conduction defects and arrhythmogenic substrates preceding paroxysmal AF.
Keyphrases
- atrial fibrillation
- catheter ablation
- left atrial
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- heart failure
- percutaneous coronary intervention
- transcription factor
- high fat diet induced
- type diabetes
- acute coronary syndrome
- adipose tissue
- metabolic syndrome
- coronary artery disease
- skeletal muscle