Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells.
Nima PurvisSweta KumariDhananjie ChandrasekeraJayanthi Bellae PapannaraoSophie GandhiIsabelle van HoutSean CoffeyRichard BuntonRamanen SugunesegranDominic ParryPhilip DavisMichael J A WilliamsAndrew BahnRajesh G KatarePublished in: Diabetologia (2021)
Our results demonstrate that diabetes mellitus induces a marked dysregulation of miRNAs associated with stem cell survival, proliferation and differentiation, and that therapeutic overexpression of prosurvival miR-30c-5p reduced diabetes-induced cell death and loss of MMP in CPCs via the newly identified target for miR-30c-5p, VDAC1.