A map of human breast cancer: new players in stromal-immune crosstalk.

Published in: The EMBO journal (2020)

Prominent accumulation of mesenchymal cells within tumors has long been appreciated, and recent studies suggest molecular and functional diversity of stromal components. In this issue, Wu et al (2020) employed single-cell RNA sequencing of primary human breast tumors and identified new subsets of stromal mesenchymal cells with distinct transcriptional profiles, tissue localization, and associative immune microenvironments.

Keyphrases

bone marrow
single cell
induced apoptosis
endothelial cells
cell cycle arrest
stem cells
induced pluripotent stem cells
gene expression
transcription factor
oxidative stress
single molecule