Preoperative Chemoradiotherapy plus Nivolumab before Surgery in Patients with Microsatellite Stable and Microsatellite Instability-High Locally Advanced Rectal Cancer.
Hideaki BandoYuichiro TsukadaKoji InamoriYosuke TogashiShohei KoyamaDaisuke KotaniShota FukuokaSatoshi YukiYoshito KomatsuShigenori HommaAkinobu TaketomiMamoru UemuraTakeshi KatoMakoto FukuiMasashi WakabayashiNaoki NakamuraMotohiro KojimaHiroshi KawachiRichard KirschTsutomu YoshidaYutaka SuzukiAkihiro SatoHiroyoshi NishikawaMasaaki ItoTakayuki YoshinoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
CRT followed by consolidation nivolumab could increase pCR. PD-L1 expression and an elevated CD8/eTreg ratio were positive predictors in patients with MSS LARC.