Modulating gut dysbiosis and mitochondrial dysfunction in oxazolone-induced ulcerative colitis: the restorative effects of β-glucan and/or celastrol.

Omnia Safwat El-DeebRasha Osama El-EsawyHanan Alsaeid Al-ShenawyHeba Bassiony Ghanem

Published in: Redox report : communications in free radical research (2022)

Mutual use of β- Glucan and Celastrol had a greater effect than each alone against UC, which is considered a novel finding highlighting the ameliorative effects of this combined treatment in modulating Microbiome/Mitochondria axis, thus launching promising avenues for UC.

Keyphrases

ulcerative colitis
signaling pathway
high glucose
diabetic rats
cell death
reactive oxygen species
endoplasmic reticulum