To cheat or not to cheat: cheatable and non-cheatable virulence factors in Pseudomonas aeruginosa.
Katya Dafne Guadarrama-OrozcoCaleb Perez-GonzalezKokila KotaMiguel Cocotl-YañezJesús Guillermo Jiménez-CortésMiguel Díaz-GuerreroMariel Hernández-GarnicaJulia MunsonFrederic CadetLuis Esaú López-JácomeÁngel Yahir Estrada-VelascoAna María Fernández-PresasRodolfo Garcia-ContrerasPublished in: FEMS microbiology ecology (2023)
Important bacterial pathogens such as Pseudomonas aeruginosa produce several exoproducts such as siderophores, degradative enzymes, biosurfactants and exopolysaccharides that are used extracellularly, benefiting all members of the population, hence being public goods. Since the production of public goods is a cooperative trait, it is in principle susceptible to cheating by individuals in the population who do not invest in their production, but use their benefits, hence increasing their fitness at the expense of the cooperators' fitness. Among the most studied virulence factors susceptible to cheating are siderophores and exoproteases, with several studies in vitro and some in animal infection models. In addition to these two well-known examples, cheating with other virulence factors such as exopolysaccharides, biosurfactants, eDNA production, secretion systems and biofilm formation has also been studied. In this review we discuss the evidence of the susceptibility of each of those virulence factors to cheating, as well as the mechanisms that counteract this behavior and the possible consequences for bacterial virulence.