Methotrexate therapy associated with a reduced rate of new-onset uveitis in patients with biological-naïve juvenile idiopathic arthritis.
Joeri W van StraalenGörkem AkayCarlyn V KouwenbergSytze de RoockViera Kalinina AyusoNico M WulffraatJoke de BoerJoost F SwartPublished in: RMD open (2023)
This study demonstrates an independent protective effect of MTX on new-onset uveitis in patients with biological-naïve JIA. Clinicians might consider early initiation of MTX in patients at high uveitis risk. We advocate more frequent ophthalmologic screening in the first 6-12 months after MTX discontinuation.