Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome.
Tanya M MonaghanTim J SloanStephen R StockdaleAdam Mark BlanchardRichard David EmesMark H WilcoxRima BiswasRupam NashineSonali MankeJinal GandhiPratishtha JainShrejal BhotmangeShrikant AmbalkarAshish SatavLorraine A DraperColin HillRajpal Singh KashyapPublished in: Gut microbes (2020)
We report distinct differences in antimicrobial resistance gene profiles, enrichment of metabolic pathways and phage composition between rural and urban populations, as well as a higher burden of Clostridioides difficile disease in the urban population. Our results reveal that geography is the key driver of variation in urban and rural Indian microbiomes, with acute diarrheal disease, including C. difficile disease exerting a lesser impact. Future studies will be required to understand the potential role of dietary, cultural, and genetic factors in contributing to microbiome differences between rural and urban populations.
Keyphrases
- antimicrobial resistance
- south africa
- liver failure
- genome wide
- pseudomonas aeruginosa
- copy number
- risk assessment
- gene expression
- intensive care unit
- risk factors
- single cell
- dna methylation
- transcription factor
- cystic fibrosis
- acute respiratory distress syndrome
- hepatitis b virus
- human health
- extracorporeal membrane oxygenation