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The influence of inflammation on the characteristics of adipose-derived mesenchymal stem cells (ADMSCs) and tissue repair capability in a hepatic injury mouse model.

Jingfang XiaoXiaoyuan GongZhenlan FuXiongbo SongQinghua MaJingya MiaoRuili CaiZexuan YanShuai WangQian LiYaokai ChenLiu YangXiuwu BianYe-Miao Chen
Published in: Stem cell research & therapy (2023)
cells acquisition. However, source tissue inflammation may not significantly affect trilineage differentiation potential and proliferative capacity of MSCs. Also, MSCs obtained from differing source degrees of inflammation retain stable and similar transcriptomic profile and are both safe and efficacious for tissue repair/regeneration without detectable differences.
Keyphrases
  • mesenchymal stem cells
  • oxidative stress
  • umbilical cord
  • mouse model
  • induced apoptosis
  • stem cells
  • bone marrow
  • cell therapy
  • cell proliferation
  • risk assessment
  • rna seq
  • wound healing