Genetic liability for Prescription Opioid Use and Risk of Cardiovascular Diseases: A Multivariable Mendelian Randomization Study.

Wen-Xiong ChenLei HeHongxuan WangXiaoming RongMing ChenQingyu ShenXiangpen LiMei LiYing Peng

Published in: Addiction (Abingdon, England) (2021)

Mendelian randomization estimates provide robust evidence for the causal effects of genetic liability for prescription opioid use on an increased risk of coronary heart disease and myocardial infarction, which might be mediated by obesity-related traits.

Keyphrases

genome wide
cardiovascular disease
metabolic syndrome
heart failure
copy number
insulin resistance
type diabetes
weight loss
left ventricular
dna methylation
high fat diet induced
physical activity