Veliparib in Combination with Carboplatin and Etoposide in Patients with Treatment-Naïve Extensive-Stage Small Cell Lung Cancer: A Phase 2 Randomized Study.

Lauren Averett ByersDmitry BentsionSteven GansKonstantin PenkovChoonHee SonAnne Sibille Taofeek Kunle Owonikoko Harry J M GroenCarl M GayJunya FujimotoPatricia M de GrootMartin DunbarKingston KangLei HeVasudha SehgalJaimee GlasgowBruce Allen BachPeter Michael Ellis

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Veliparib plus platinum chemotherapy followed by veliparib maintenance demonstrated improved PFS as first-line treatment for ED-SCLC with an acceptable safety profile, but there was no corresponding benefit in OS. Further investigation is warranted to define the role of biomarkers in this setting.

Keyphrases

small cell lung cancer
emergency department
locally advanced
clinical trial
brain metastases
squamous cell carcinoma
radiation therapy
combination therapy
study protocol