Login / Signup

Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID-19.

Alexandra C AppleAlexis OddiMichael J PelusoBreton M AskenTimothy J HenrichJ Daniel KellySamuel J PleasureSteven G DeeksIsabel Elaine AllenJeffrey N MartinLishomwa C NdhlovuBruce L MillerMelanie L StephensJoanna Hellmuth
Published in: Annals of clinical and translational neurology (2022)
Cognitive post-acute sequelae of SARS-CoV-2 (PASC) can occur after mild COVID-19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS-CoV-2 infection through structured interviews, neuropsychological testing, and optional cerebrospinal fluid (CSF) evaluations (53%). Delayed onset of cognitive PASC occurred in 43% and associated with younger age. Cognitive PASC participants had a higher number of pre-existing cognitive risk factors (2.5 vs. 0; p = 0.03) and higher proportion with abnormal CSF findings (77% vs. 0%; p = 0.01) versus controls. Cognitive risk factors and immunologic mechanisms may contribute to cognitive PASC pathogenesis.
Keyphrases
  • sars cov
  • risk factors
  • cerebrospinal fluid
  • coronavirus disease
  • emergency department
  • intensive care unit
  • adverse drug
  • mechanical ventilation
  • electronic health record