Neuropathological Variability within a Spectrum of NMDAR-Encephalitis.

Tobias ZrzavyVerena EndmayrJan BauerStefan MacherNilufar MossahebCarmen SchwaigerGerda RickenMichael WinklehnerSarah GlatterMarkus BreuIsabella WimmerGábor G KovácsDaniele U RisserNikolaus KluppIngrid Simonitsch-KluppThomas RoetzerPaulus RommerThomas BergerEllen GelpíHans LassmannFrancesc GrausJosep DalmauRomana Höftberger

Published in: Annals of neurology (2021)

The topographic distribution of inflammation in patients with NMDAR-encephalitis reflects the clinical symptoms of movement disorders, abnormal behavior, and memory dysfunction with inflammation dominantly observed in basal ganglia, amygdala, and hippocampus, and loss of NMDAR-immunoreactivity correlates with disease severity. Co-occurring pathologies influence the spatial distribution, composition, and intensity of inflammation, which may modify patients' clinical presentation and outcome. ANN NEUROL 2021;90:725-737.

Keyphrases

oxidative stress
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
physical activity
cerebral ischemia
blood brain barrier
temporal lobe epilepsy