Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy.

Marine GueugneauDonatienne d'HoseCaroline BarbéMarie de BarsyPascale LauseDominique MaiterLaure B BindelsNathalie M DelzenneLaurent SchaefferYann-Gaël GangloffChristophe ChambonCécile Coudy-GandilhonDaniel BéchetJean-Paul Thissen

Published in: Journal of cachexia, sarcopenia and muscle (2018)

Taken together, these data suggest that Serpina3n may represent a circulating biomarker of muscle atrophy associated to GC and, broadly, a reflection of dynamic changes in muscle mass.

Keyphrases

skeletal muscle
electronic health record
big data
machine learning
gas chromatography
tandem mass spectrometry
simultaneous determination