Optimal dosing regimen of CD73 blockade improves tumor response to radiotherapy through iCOS downregulation.

Lydia MezianiMarine Gerbé de ThoréCéline ClémensonWinchygn LiuPierre-Antoine LaurentMichele MondiniMarie-Catherine VozeninEric Deutsch

Published in: Journal for immunotherapy of cancer (2023)

These data emphasize the importance of the dosing regimen for anti-CD73 treatment to improve tumor response to IR and identify iCOS as part of the underlying molecular mechanisms. Our data suggest that the selection of appropriate dosing regimen is required to optimize the therapeutic efficacy of immunotherapy-radiotherapy combinations.

Keyphrases

early stage
electronic health record
radiation therapy
radiation induced
locally advanced
big data
nk cells
cell proliferation
squamous cell carcinoma
machine learning
rectal cancer