Sex-Dependent Effects of Nephron Ift88 Disruption on BP, Renal Function, and Cystogenesis.
Chunyan HuJayalakshmi LakshmipathiElizabeth BinningKelly A HyndmanDeborah StuartDonald E KohanPublished in: Journal of the American Society of Nephrology : JASN (2021)
Nephron cilia disruption in male, but not female, mice (1) reduces BP prior to cyst formation, (2) increases NOx production that may account for the lower BP prior to cyst formation, and (3) induces polycystic kidneys that are associated with hypertension and reduced renal NO production.
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