Meta-analysis of the risk of autoimmune thyroiditis, Guillain-Barré syndrome, and inflammatory bowel disease following vaccination with AS04-adjuvanted human papillomavirus 16/18 vaccine.

Dominique Rosillon Corinne WillameFernanda Tavares Da SilvaAdrienne GuignardSophie CaterinaSarah WelbyFrank Struyf

Published in: Pharmacoepidemiology and drug safety (2020)

This meta-analysis did not show an increased risk of IBD following vaccination with AS04-HPV-16/18. The 1.5-fold increased risk of (autoimmune) thyroiditis does not allow us to conclude about a causal association. For GBS, the very low number of cases and wide 95% CIs negate any firm conclusion.

Keyphrases

systematic review
meta analyses
multiple sclerosis
case control
case report
cervical cancer screening