Seeding variability of different alpha synuclein strains in synucleinopathies.
Niccolò CandeliseMatthias SchmitzFranc LlorensAnna Villar-PiquéMaria CrammTobias ThomSusana Margarida da Silva CorreiaJosé Eriton Gomes da CunhaWiebke MöbiusTiago F OuteiroValentina González ÁlvarezMartina BanchelliCristiano D'AndreaMarella de AngelisSaima ZafarAlberto RabanoPaolo MatteiniInga ZerrPublished in: Annals of neurology (2019)
Structural variances of α-synuclein seeding kinetics and products in DLB and PD indicated, for the first time, the existence of different α-synuclein strains in these groups. Therefore, our study contributes to a better understanding of the clinical heterogeneity among α-synucleinopathies, offers an opportunity for a specific diagnosis, and opens new avenues for the future development of strain-specific therapies. Ann Neurol 2019;85:691-703.