Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy.
Miguel Lopez-CuinaPaul A GuerinMarie-Hélène CanronAnna DelamarreBenjamin DehayErwan BezardWassillios G MeissnerPierre Olivier FernagutPublished in: Movement disorders : official journal of the Movement Disorder Society (2020)
This preclinical study suggests that partial inhibition of c-Abl and reduction of α-synuclein phosphorylation at tyrosine 39 may not be a relevant target for MSA. © 2020 International Parkinson and Movement Disorder Society.