Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy.

Miguel Lopez-CuinaPaul A GuerinMarie-Hélène CanronAnna DelamarreBenjamin DehayErwan BezardWassillios G Meissner Pierre Olivier Fernagut

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

This preclinical study suggests that partial inhibition of c-Abl and reduction of α-synuclein phosphorylation at tyrosine 39 may not be a relevant target for MSA. © 2020 International Parkinson and Movement Disorder Society.

Keyphrases

mouse model
cell therapy
chronic myeloid leukemia
single cell
stem cells
protein kinase