MRI biomarkers and neuropsychological assessments of hippocampal and parahippocampal regions affected by ALS: A systematic review.
Sana MohammadiSadegh GhaderiFarzad FatehiPublished in: CNS neuroscience & therapeutics (2024)
The hippocampus and the connected regions are involved in ALS. Hippocampal atrophy disrupted connectivity and metabolite changes correlate with cognitive and functional decline. Specific subregions can be particularly affected. The hippocampus is a potential biomarker for disease monitoring and prognosis.
Keyphrases
- cerebral ischemia
- resting state
- amyotrophic lateral sclerosis
- subarachnoid hemorrhage
- blood brain barrier
- brain injury
- functional connectivity
- magnetic resonance imaging
- prefrontal cortex
- cognitive impairment
- contrast enhanced
- mild cognitive impairment
- temporal lobe epilepsy
- white matter
- computed tomography
- multiple sclerosis