Association of serum PCSK9 levels with platelet function in patients with acute coronary syndromes.

Wenting WangRonghua LuoDean PeiQi HuangXinyao JinYuanhong WuMingbin XieShisheng WangXiangqian SuiBin Shen

Published in: Medicine (2023)

This study will reveal possible relationship between serum PCSK9 and platelet reactivity in the setting of ACS which may shed light on therapeutic potential in platelet inhibition by targeting PCSK9. The study will also explore the association of serum PCSK9 and platelet-ox-LDL binding, an important mechanism for platelet-LDL interplay, to provide mechanistic insight into PCSK9-mediated regulation of platelet reactivity.

Keyphrases

low density lipoprotein
acute coronary syndrome
genome wide
single cell
dna binding
transcription factor