Proton Craniospinal Irradiation with Immunotherapy in Two Patients with Leptomeningeal Disease from Melanoma.

Ugur T Sener Mason James WebbWilliam G BreenBryan J NethNadia N LaackDavid RoutmanPaul D BrownAnita MahajanKelsey FrechetteArkadiusz Z DudekSvetomir N MarkovicMatthew S BlockRobert R McWilliamsAnastasios DimouLisa A KottschadeHeather N MontaneSani H KizilbashJian L Campian

Published in: Journal of immunotherapy and precision oncology (2024)

Adding an ICI to pCSI is feasible for patients with LMD and demonstrates a tolerable toxicity profile. While prospective evaluation is ultimately warranted, pCSI with ICI may confer survival benefits, even after prior ICI.

Keyphrases

oxidative stress
small cell lung cancer
free survival
radiation induced
radiation therapy
skin cancer
basal cell carcinoma