BMP4 regulates asymmetric Pkd2 distribution in mouse nodal immotile cilia and ciliary mechanosensing required for left-right determination.
Takanobu A KatohTim LangeYoshiro NakajimaKenta YashiroYasushi OkadaHiroshi HamadaPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2024)
Experimental data together with model calculations suggest that BMP4 regulates the asymmetric distribution of Pkd2 in nodal immotile cilia, thereby affecting the ability of these cilia to sense the bending direction for L-R determination. This study, for the first time, provides insight into the relationship between the asymmetric protein distribution in cilia and their function.
Keyphrases
- mesenchymal stem cells
- lymph node
- neoadjuvant chemotherapy
- solid phase extraction
- polycystic kidney disease
- molecularly imprinted
- molecular dynamics simulations
- density functional theory
- squamous cell carcinoma
- big data
- machine learning
- bone regeneration
- binding protein
- artificial intelligence
- rectal cancer
- simultaneous determination
- locally advanced