Pd-Catalyzed coupling of benzyl bromides with BMIDA-substituted N -tosylhydrazones: synthesis of trans -alkenyl MIDA boronates.

A palladium-catalyzed stereoselective synthesis of alkenyl boronates from N -methyliminodiacetyl boronate (BMIDA)-substituted N -tosylhydrazone and benzyl bromides is developed. A range of trans -alkenyl MIDA boronates as single stereoisomers were obtained in moderate yields with good functional group compatibility. The resultant boronate products may be transformed to other boron-containing compounds and may also be directly used in cross-coupling reactions.