Reduction in pappalysin-2 levels and lower IGF-I bioavailability in female adolescents with anorexia nervosa.

Vicente Barrios-Sabador Álvaro Martín-Rivada Santiago Guerra-CanteraAna Campillo-CalatayudRicardo A CamarneiroMontserrat Graell Julia A Chowen Jesús Argente

Published in: The Journal of clinical endocrinology and metabolism (2023)

The reduction of PAPP-A2 in patients with AN may be involved in a decline in IGFBP cleavage, which could underlie the decrease in IGF-I bioavailability that is influenced by nutritional status and amenorrhea.

Keyphrases

anorexia nervosa
young adults
binding protein
pi k akt
physical activity
growth hormone