The classical and alternative circulating renin-angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease.
Hillary H HammondMarisa K AmesOliver DomenigBrian A ScansenNuen Tsang YangMachelle D WilsonErin SunshineKaitlyn BrunkAllison MastersPublished in: Journal of veterinary internal medicine (2023)
Circulating alternative RAS activity, specifically the surrogate measure of ACE2 activity, was increased in dogs with stage B2 MMVD as compared to normal dogs. Equilibrium dialysis results are analogous to immediate protease inhibition in dogs.