Molecular detection of multidrug resistance pattern and associated gene mutations in M. tuberculosis isolates from newly diagnosed pulmonary tuberculosis patients in Addis Ababa, Ethiopia.
Melaku TilahunEzra ShimelisTeklu WogayehuGebeyehu AssefaGetachew WondimagegnAlemayehu MekonnenTsegaye HailuKidist BoboshaAbraham AseffaPublished in: PloS one (2020)
In our finding a relatively high prevalence of any drug resistance was observed and the overall prevalence of multidrug-resistant tuberculosis was 1.1%.The majority of drug-resistant isolates demonstrated common mutations. Heteroresistant strains were detected, signaling the existence of an M.tuberculosis population with variable responses to anti-tuberculosis drugs or of mixed infections.
Keyphrases
- pulmonary tuberculosis
- drug resistant
- multidrug resistant
- mycobacterium tuberculosis
- newly diagnosed
- acinetobacter baumannii
- end stage renal disease
- hiv aids
- gram negative
- ejection fraction
- chronic kidney disease
- escherichia coli
- risk factors
- emergency department
- adverse drug
- human immunodeficiency virus
- drug induced
- hiv infected
- antiretroviral therapy