Rejuvenation of Mesenchymal Stem Cells to Ameliorate Skeletal Aging.
Mingjia ChengWeihao YuanAlireza MoshaveriniaBo YuPublished in: Cells (2023)
Advanced age is a shared risk factor for many chronic and debilitating skeletal diseases including osteoporosis and periodontitis. Mesenchymal stem cells develop various aging phenotypes including the onset of senescence, intrinsic loss of regenerative potential and exacerbation of inflammatory microenvironment via secretory factors. This review elaborates on the emerging concepts on the molecular and epigenetic mechanisms of MSC senescence, such as the accumulation of oxidative stress, DNA damage and mitochondrial dysfunction. Senescent MSCs aggravate local inflammation, disrupt bone remodeling and bone-fat balance, thereby contributing to the progression of age-related bone diseases. Various rejuvenation strategies to target senescent MSCs could present a promising paradigm to restore skeletal aging.
Keyphrases
- mesenchymal stem cells
- dna damage
- oxidative stress
- bone mineral density
- umbilical cord
- bone marrow
- postmenopausal women
- cell therapy
- dna repair
- soft tissue
- stem cells
- bone loss
- bone regeneration
- gene expression
- ischemia reperfusion injury
- chronic obstructive pulmonary disease
- body composition
- dna methylation
- adipose tissue
- stress induced
- risk assessment
- climate change
- platelet rich plasma
- human health