Improved Gene Fusion Detection in Childhood Cancer Diagnostics Using RNA Sequencing.
Jayne Y Hehir-KwaMarco J KoudijsEugene T P VerwielLennart A KesterMarc van TuilEric StrengmanArjan BuijsMariëtte E G KranendonkLaura S Hiemcke-JiwaValerie de HaasEllen van de GeerWendy de LengJasper van der LugtPhilip LijnzaadFrank C P HolstegePatrick KemmerenBastiaan B J TopsPublished in: JCO precision oncology (2022)
We show that RNA sequencing is sufficiently robust for gene fusion detection in routine diagnostics of childhood cancers and can make a difference in treatment decisions.