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Whole-genome sequencing establishes persistence of biofilm-associated Pseudomonas aeruginosa detected from microbiological surveillance of gastrointestinal endoscopes.

G S E TanG J M ChiaN M ThevasagayamS Q D LoyS R S PrakkiZ Q LimJ Y ChuaJ W Z ChiaK MarimuthuS VasooO T NgB F PohB S P Ang
Published in: The Journal of hospital infection (2024)
The WGS findings helped to deprioritize common source contamination and supported the hypothesis of biofilm build-up within endoscopes, leading to repeatedly positive MS cultures that were genomically linked. This was possibly related to incomplete reprocessing of the damaged air/water valves, resulting in biofilm build-up. All faulty valves were changed and subsequently cleaned separately with ultrasonic cleaning followed by sterilization which resolved this incident.
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