Akkermansia muciniphila and Parabacteroides distasonis synergistically protect from colitis by promoting ILC3 in the gut.

Joana GaifemAna Mendes-FriasMathis WolterAlex SteimleMaria Jose GarzónCarles UbedaClarisse NobreAbigail GonzálezSalomé S PinhoCristina CunhaAgostinho CarvalhoAntónio Gil CastroMahesh S Desai Fernando Rodrigues Ricardo Silvestre

Published in: mBio (2024)

, which induce protection against both acute and chronic models of colitis induction, by enhancing epithelial barrier integrity and promoting group 3 innate lymphoid cells in the colonic mucosa. This study provides a novel insight on how commensal bacteria can beneficially act to promote intestinal homeostasis, which may open new avenues toward the use of microbiome-derived strategies to tackle IBD.

Keyphrases

ulcerative colitis
induced apoptosis
liver failure
cell cycle arrest
drug induced
minimally invasive
respiratory failure
cell death
intensive care unit
extracorporeal membrane oxygenation
pi k akt