Cystobactamids 920-1 and 920-2: Assignment of the Constitution and Relative Configuration by Total Synthesis.

Therese PlankeMaría MorenoStephan HüttelJörg FohrerFranziska GilleMatthew D NorrisMaik SiebkeLiangliang WangRolf MüllerAndreas Kirschning

Published in: Organic letters (2019)

Total synthesis of cystobactamid 920-1 and its epimer has allowed an unambiguous assignment of the relative and absolute configuration of the natural product. A careful structural analysis of each isomer using both NMR and computational techniques also prompted a constitutional revision of the structures originally reported for cystobactamids 920-1 and 920-2, and has provided further insight into the unique conformational preferences of the cystobactamid family.

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