Model-Based Analysis of IGF-I Response, Dosing, and Monitoring for Once-Weekly Somapacitan in Children With GH Deficiency.

Rasmus Juul KildemoesPhilippe F BackeljauwMichael Højby RasmussenJoanne C BlairBradley S Miller Jun MoriYassine K Lyauk

Published in: Journal of the Endocrine Society (2023)

We characterized the dose-IGF-I response of somapacitan in children with GHD. To support physicians in IGF-I monitoring, we present a practical guide about expected weekly average IGF-I concentrations in these patients and provide insights on dosing day flexibility.

Keyphrases

growth hormone
binding protein
pi k akt
end stage renal disease
young adults
ejection fraction
primary care
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
cell proliferation
patient reported outcomes
patient reported