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Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems.

Jinhua WenYuwei XiaoMenghua ZhaoChen YangWeiqiang Hu
Published in: Current drug metabolism (2024)
Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.
Keyphrases
  • helicobacter pylori
  • helicobacter pylori infection