Co-occurrence of orofacial clefts and clubfoot phenotypes in a sub-Saharan African cohort: Whole-exome sequencing implicates multiple syndromes and genes.

Lord Jephthah Joojo GowansNoura Al DhaheriMary LiTamara BuschSolomon Obiri-YeboahAlexander A OtiDaniel K SabbahFareed K N ArthurWaheed O AwotoyeAzeez Arisekola AladePeter TwumasiPius AgbenorkuGyikua Plange-RhuleThirona NaickerPeter DonkorJeffrey C MurrayNara L M SobreiraAzeez Butali

Published in: Molecular genetics & genomic medicine (2021)

Our results suggest that clubfoot and OFCs are two congenital abnormalities that can co-occur in certain individuals with varying genetic causes and expressivity, warranting the need for deep phenotyping.

Keyphrases

genome wide
high throughput
dna methylation
genome wide identification
bioinformatics analysis
gene expression
genome wide analysis
transcription factor