Engineered biosynthesis of plant heteroyohimbine and corynantheine alkaloids in Saccharomyces cerevisiae.
Moriel J DrorJoshua MisaDanielle A YeeAngela M ChuRachel K YuBradley B ChanLauren S AoyamaAnjali P ChaparalaSarah E O'ConnorYi TangPublished in: Journal of industrial microbiology & biotechnology (2024)
An Saccharomyces cerevisiae-based microbial platform was developed for the biosynthesis of monoterpene indole alkaloids, including the universal precursor strictosidine and further modified heteroyohimbine and corynantheidine alkaloids.