Near-infrared light-responsive Nitric oxide microcarrier for multimodal tumor therapy.
Danna LiangGaizhen KuangXiang ChenJianhua LuLuoran ShangWeijian SunPublished in: Smart medicine (2023)
Nitric oxide (NO) has shown great potential in tumor therapy, and the development of a platform for precise and controllable NO release still needs to be explored. Herein, a microfluidic electrospray strategy is proposed for the fabrication of hydrogel microspheres encapsulating NO donors (S-nitrosoglutathione, GSNO) together with black phosphorus (BP) and chemotherapeutic doxorubicin (DOX) as microcarriers for tumor therapy. Based on the excellent photothermal property of BP and thermal sensitivity of GSNO, the microcarriers exhibit a near-infrared light (NIR)-responsive NO release behavior. Besides, the photothermal performance of the microcarriers accelerates the release of DOX. All these contribute to the excellent tumor-killing effect of the microcarriers by combining multiple therapeutic strategies including NO therapy, photothermal therapy, and chemotherapy. Moreover, it was demonstrated that the NIR-responsive NO delivery microcarriers could significantly inhibit tumor growth without apparent side effects in vivo. Therefore, it is believed that the novel NIR-responsive NO microcarriers are promising candidates in clinical tumor therapy applications.
Keyphrases
- nitric oxide
- cancer therapy
- photodynamic therapy
- drug delivery
- drug release
- magnetic resonance imaging
- stem cells
- squamous cell carcinoma
- high throughput
- fluorescence imaging
- hydrogen peroxide
- magnetic resonance
- chronic pain
- pain management
- climate change
- cell therapy
- simultaneous determination
- replacement therapy
- wound healing