Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague-Dawley rats.

Gavin N PetrieKiri L WillsFabiana PiscitelliReem SmoumCheryl L LimebeerErin M RockAshlyn E HumphreyMadeleine Sheppard-PerkinsAron H LichtmanRaphael MechoulamVincenzo Di MarzoLinda A Parker

Published in: Psychopharmacology (2019)

Here, we show that OlGly interferes with the aversive properties of acute naloxone-precipitated morphine withdrawal in rats. These results suggest that OlGly may reduce the impact of MWD and may possess efficacy in treating opiate withdrawal.

Keyphrases

liver failure
respiratory failure
drug induced
aortic dissection
hepatitis b virus
intensive care unit
mechanical ventilation