Systematic overdosing of oxa- and cloxacillin in severe infections treated in ICU: risk factors and side effects.
Mathilde NeuvilleNajoua El-HelaliEric MagalhaesAguila RadjouRoland SmonigJean-François SoubirouGuillaume VoiriotAlban Le MonnierStéphane RucklyLila BouadmaRomain SonnevilleJean-François TimsitBruno MourvillierPublished in: Annals of intensive care (2017)
With the suggested dose of 12 g/day for cloxacillin treatment in case of endocarditis and severe infections occurring in ICU, 83.9% of patients are largely overdosed. Considering the observed side effects, doses should be accurately monitored and reduced, particularly when renal replacement therapy is needed.
Keyphrases
- risk factors
- end stage renal disease
- intensive care unit
- newly diagnosed
- ejection fraction
- chronic kidney disease
- early onset
- acute kidney injury
- mechanical ventilation
- prognostic factors
- peritoneal dialysis
- escherichia coli
- acinetobacter baumannii
- patient reported outcomes
- drug resistant
- drug induced
- pseudomonas aeruginosa
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- smoking cessation