Circ_0008146 Exacerbates Ferroptosis via Regulating the miR-342-5p/ACSL4 Axis After Cerebral Ischemic/Reperfusion.

Cai-Dong LiuQiang PengShi-Yao WangYang DengZhong-Yuan LiZhao-Han XuLiang WuYing-Dong ZhangRui Duan

Published in: Journal of inflammation research (2024)

This study provides the first in vivo evidence to show that circ_0008146 exacerbates neuronal ferroptosis after AIS via the miR-342-5p/ACSL4 axis. Furthermore, miR-342-5p/ACSL4 axis holds promise as a viable therapeutic target and practical biomarkers for AIS patients.

Keyphrases

cerebral ischemia
cell death
end stage renal disease
ejection fraction
chronic kidney disease
subarachnoid hemorrhage
acute myocardial infarction
prognostic factors
patient reported
atrial fibrillation