The antidepressant effect and safety of non-intranasal esketamine: A systematic review.

Sanne Y Smith-ApeldoornMaurice VischjagerJolien Ke VeraartJeanine KamphuisMarije Aan Het RotRobert A Schoevers

Published in: Journal of psychopharmacology (Oxford, England) (2022)

Intravenous, subcutaneous, and possibly oral esketamine may offer an effective and safe addition to the depression treatment armamentarium. However, as most included studies lacked a control group and had small sample sizes, the quality of our results is limited. Different types and formulations of ketamine remain to be compared directly.

Keyphrases

major depressive disorder
depressive symptoms
pain management
sleep quality
low dose
physical activity
bipolar disorder