Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging.

Suk Hyun LeeHyunsu SohJin Hwa ChungEun Hye ChoSang Ju LeeJi-Min JuJoong Hyuk SheenHyori KimSeung Jun OhSang-Jin LeeJunho ChungKyungho ChoiSeog-Young KimJin-Sook Ryu

Published in: PloS one (2020)

Real-time in vivo cell trafficking is feasible using PET imaging of 89Zr-DFO-labeled CAR T-cells. This can be used to investigate cellular kinetics, initial in vivo biodistribution, and safety profiles in future CAR T-cell development.

Keyphrases

pet imaging
positron emission tomography
single cell
cell therapy
current status
computed tomography
mesenchymal stem cells