Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV.
Gopalan NarendranDhanasekaran KavithaRamesh KarunaiananthamLeonardo Gil-SantanaJilson L Almeida-JuniorSirasanambatti Devarajulu ReddyMarimuthu Makesh KumarHaribabu HemalathaNagesh Nalini JayanthiNarayanan RavichandranRaja KrishnarajaAngamuthu PrabhakarTamizhselvan ManoharanLokeswaran NithyananthanGunasundari ArjunanMohan NatrajanSoumya SwaminathanBruno Bezerril AndradePublished in: PloS one (2016)
A higher incidence of severe IRIS among patients with mutant LTA4H genotypes (CT and TT) was observed compared to the wild type, despite similar IRIS incidence and immune restoration in both groups. Steroids were effective in alleviating IRIS in all the genotypes.
Keyphrases
- wild type
- end stage renal disease
- risk factors
- hiv aids
- ejection fraction
- newly diagnosed
- antiretroviral therapy
- human immunodeficiency virus
- chronic kidney disease
- risk assessment
- hepatitis c virus
- computed tomography
- oxidative stress
- hiv positive
- mycobacterium tuberculosis
- peritoneal dialysis
- prognostic factors
- magnetic resonance imaging
- case report
- patient reported outcomes
- contrast enhanced
- positron emission tomography
- hiv testing
- pet ct