Determination of intracellular tenofovir-diphosphate and emtricitabine-triphosphate concentrations in dried blood spots for pre-exposure prophylaxis adherence.

Kiyoto TsuchiyaYoshiharu HayashiShoraku RyuHieu Trung TranMisao TakanoKazuko TanakaDaisuke MizushimaShinichi OkaHiroyuki GatanagaAkinobu Hamada

Published in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (2024)

A multiplex LC-MS/MS method was successfully developed for DBS, which can be useful for monitoring the levels of TFV-DP and FTC-TP in individuals receiving PrEP.

Keyphrases

men who have sex with men
deep brain stimulation
solid phase extraction
high throughput
molecularly imprinted
real time pcr
antiretroviral therapy
reactive oxygen species
metabolic syndrome
adipose tissue
liquid chromatography