Topical metformin suppresses angiogenesis pathways induced by pulsed dye laser irradiation in animal models.
Meiling WangYan LinWenhao ShiXuechao ChenZihao MiZhiwei JiaQing PanZhenzhen WangJian HanHuaxu LiuPublished in: Experimental dermatology (2021)
Pulsed dye laser (PDL) is the first-line treatment for port-wine stain (PWS). However, only a small portion of the lesions could be completely cleared by PDL treatment, which might be related to the regeneration and revascularization of the vascular structures after laser irradiation. Recently, it is believed that the suppression of regeneration and revascularization of photocoagulated blood vessels can achieve a better therapeutic outcome. We use rabbit ear and SD rat as the animal models to investigate whether PDL-induced angiogenesis can be suppressed by topical metformin. Our results showed that topical application of metformin can effectively suppress the PDL-induced early stage of angiogenesis via inhibition of the AKT/mTOR/P70S6K pathway in animal models.
Keyphrases
- wound healing
- endothelial cells
- high glucose
- early stage
- stem cells
- vascular endothelial growth factor
- diabetic rats
- cell proliferation
- coronary artery bypass grafting
- percutaneous coronary intervention
- drug induced
- high speed
- oxidative stress
- high resolution
- coronary artery disease
- robot assisted
- sentinel lymph node