Pregnancy Serum DLK1 Concentrations Are Associated With Indices of Insulin Resistance and Secretion.

Clive J PetryKeith A BurlingPeter BarkerIeuan A HughesKen K OngDavid B Dunger

Published in: The Journal of clinical endocrinology and metabolism (2021)

These results are consistent with a partial paternal or placental origin for the maternal circulating DLK1 which may lead to increased maternal circulating DLK1 concentrations, stimulation of maternal insulin resistance and compensatory hyperinsulinemia during pregnancy, and the promotion of fetal growth.

Keyphrases

insulin resistance
pregnancy outcomes
birth weight
adipose tissue
type diabetes
metabolic syndrome
high fat diet
skeletal muscle
preterm birth
weight gain
body mass index
physical activity