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Endogenous IL-27 during toxoplasmosis limits early monocyte responses and their inflammatory activation by pathological T cells.

Daniel L AldridgeDevapregasan MoodleyJeongho ParkAnthony T PhanMatthew RauschKerry F WhiteYue RenKarin GolinEnrico RadaelliRoss KedlPamela M HollandJonathan HillChristopher A Hunter
Published in: mBio (2024)
. In the absence of IL-27, a lethal, overactive immune response develops during infection. However, when exactly in the course of infection this molecule is needed was unclear. By selectively inhibiting IL-27 during this parasitic infection, we discovered that IL-27 was only needed during, but not prior to, infection. Additionally, IL-27 is only needed in the active areas in which the parasite is replicating. Finally, our work found that a previously unstudied cell type, monocytes, was regulated by IL-27, which contributes further to our understanding of the regulatory networks established by this molecule.
Keyphrases
  • immune response
  • oxidative stress
  • endothelial cells
  • peripheral blood
  • inflammatory response