ISSLS PRIZE IN BASIC SCIENCE 2017: Intervertebral disc/bone marrow cross-talk with Modic changes.

Stefan DudliDavid C SingSerena S HuSigurd H BervenShane BurchVedat DevirenIvan ChengBobby K B TayTodd F AlaminMa Agnes Martinez IthEric M PietrasJeffrey C Lotz

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2017)

Our data reveal a fibrogenic and pro-inflammatory cross-talk between MC bone marrow and adjacent discs. This provides insight into the pain generator at MC levels and informs novel therapeutic targets for treatment of MC-associated LBP.

Keyphrases

bone marrow
mesenchymal stem cells
chronic pain
public health
pain management
electronic health record
neuropathic pain
genome wide
single cell
big data
gene expression