A Multi-Omics Atlas of Sex-Specific Differences in Obstructive Hypertrophic Cardiomyopathy.

Ramin GarmanySurendra DasariJ Martijn BosEvelyn T KimKatherine A MartinezDavid J TesterCristobal Dos RemediosJoseph J MaleszewskiJoseph A DearaniSteve R OmmenJeffrey B GeskeJohn R GiudicessiMichael J Ackerman

Published in: bioRxiv : the preprint server for biology (2024)

There are subtle, but biologically relevant differences in the multi-omics profile of HCM. This study provides the most comprehensive atlas of sex-specific differences in the transcriptome, proteome, and phosphoproteome present at the time of surgical myectomy for obstructive HCM.

Keyphrases

hypertrophic cardiomyopathy
single cell
left ventricular
rna seq
gene expression
heart failure
genome wide
dna methylation
atrial fibrillation