Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia.
Maryam MohammadiHossein Asgarian-OmranBehnam NajafiAhmad NajafiReza ValadanHossein KaramiMohammad NaderisorakiMaryam Alizadeh ForutanRamin ShekarrizMohsen TehraniPublished in: Iranian journal of immunology : IJI (2023)
NR4As expressions were found to be lower in CD8+ T cells from patients with AML and ALL compared to controls, whereas the mRNA expression of TOX showed no significant difference. Although TOX and NR4As are associated with CD8+ T cell exhaustion in solid tumors, they might play different roles in acute leukemia, which requires further investigation.